Research

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Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy

Junlai Wan, Zhiyi He, Renpeng Peng, Xiaopei Wu, Ziqing Zhu, Jiarui Cui, Xiaoxia Hao, Anmin Chen, Jiaming Zhang, Peng Cheng

Journal of Nanobiotechnology  ·  21 Aug 2023  ·  doi:10.1186/s12951-023-02050-7

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2024

METTL3-mediated HSPA9 m6A modification promotes malignant transformation and inhibits cellular senescence by regulating exosomal mortalin protein in cervical cancer

Keyi Ao, Minuo Yin, Xiaoming Lyu, Yue Xiao, Xiaona Chen, …, Ming Ye, Jiaming Zhang, Xin Li, Yi Hao, Xia Guo

Cancer Letters  ·  01 Apr 2024  ·  doi:10.1016/j.canlet.2024.216658

Genetically Proxied Sarcopenia-Related Muscle Traits and Depression: Evidence from the FinnGen Cohort

Zhengtao Lv, Yingchao Zhao, Jiarui Cui, Jiaming Zhang

The American Journal of Geriatric Psychiatry  ·  01 Jan 2024  ·  doi:10.1016/j.jagp.2023.08.001

2023

Comparative study in estrogen-depleted mice identifies skeletal and osteocyte transcriptomic responses to abaloparatide and teriparatide

Zhengtao Lv, Jiaming Zhang, Shuang Liang, Chenhe Zhou, Dorothy Hu, …, Mary L. Bouxsein, Beate Lanske, Paul Kostenuik, Francesca Gori, Roland Baron

JCI Insight  ·  23 Oct 2023  ·  doi:10.1172/jci.insight.161932

Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy

Junlai Wan, Zhiyi He, Renpeng Peng, Xiaopei Wu, Ziqing Zhu, Jiarui Cui, Xiaoxia Hao, Anmin Chen, Jiaming Zhang, Peng Cheng

Journal of Nanobiotechnology  ·  21 Aug 2023  ·  doi:10.1186/s12951-023-02050-7

Amazing Research

Manubot

Manuscript Source

Website

open-science collaboration

Novel strategy of senescence elimination via toxicity-exempted kinome perturbations by nanoliposome-based thermosensitive hydrogel for osteoarthritis therapy

Junlai Wan, Zhiyi He, Yingchao Zhao, Xiaoxia Hao, Jiarui Cui, Anmin Chen, Jun Zhou, Jiaming Zhang

Advanced Composites and Hybrid Materials  ·  18 May 2023  ·  doi:10.1007/s42114-023-00673-w

Nanoliposomal Bcl-xL proteolysis-targeting chimera enhances anti-cancer effects on cervical and breast cancer without on-target toxicities

Jiaming Zhang, Baofang Zhang, Congli Pu, Jiarui Cui, Kexin Huang, Hongbo Wang, Yingchao Zhao

Advanced Composites and Hybrid Materials  ·  01 Apr 2023  ·  doi:10.1007/s42114-023-00649-w

2022

Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort

Zhengtao Lv, Jiarui Cui, Jiaming Zhang

Frontiers in Immunology  ·  15 Dec 2022  ·  doi:10.3389/fimmu.2022.1065739

STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity

Zhichuan Zhu, Xin Zhou, Hongwei Du, Erica W. Cloer, Jiaming Zhang, …, Jeremy M. Simon, Jeanette Gowen Cook, Michael B. Major, Gianpietro Dotti, Pengda Liu

Advanced Science  ·  29 Nov 2022  ·  doi:10.1002/advs.202203718

Smoking, alcohol and coffee consumption and risk of low back pain: a Mendelian randomization study

Zhengtao Lv, Jiarui Cui, Jiaming Zhang

European Spine Journal  ·  16 Sep 2022  ·  doi:10.1007/s00586-022-07389-3

Unbiased comparison and modularization identify time-related transcriptomic reprogramming in exercised rat cartilage: Integrated data mining and experimental validation

Jiarui Cui, Yo Shibata, Keiji Itaka, Jun Zhou, Jiaming Zhang

Frontiers in Physiology  ·  15 Sep 2022  ·  doi:10.3389/fphys.2022.974266

Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities

Jiarui Cui, Jiaming Zhang

International Journal of Molecular Sciences  ·  17 Aug 2022  ·  doi:10.3390/ijms23169253

Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone

Jun Zhou, Zhiyi He, Jiarui Cui, Xiaoling Liao, Hui Cao, Yo Shibata, Takashi Miyazaki, Jiaming Zhang

Bone & Joint Research  ·  01 Jun 2022  ·  doi:10.1302/2046-3758.116.BJR-2021-0436.R1

Osteocytes in bone aging: Advances, challenges, and future perspectives

Jiarui Cui, Yo Shibata, Tianmin Zhu, Jun Zhou, Jiaming Zhang

Ageing Research Reviews  ·  01 May 2022  ·  doi:10.1016/j.arr.2022.101608

Emerging biomimetic nanotechnology in orthopedic diseases: progress, challenges, and opportunities

Zhongyang Zhang, Jun Zhou, Chuang Liu, Jiaming Zhang, Yo Shibata, Na Kong, Claudia Corbo, Mitchel B. Harris, Wei Tao

Trends in Chemistry  ·  01 May 2022  ·  doi:10.1016/j.trechm.2022.02.002

Exercise modifies the disease-relevant gut microbial shifts in post-traumatic osteoarthritis rats

Xiaoxia Hao, Jiaming Zhang, Xingru Shang, Kai Sun, Jun Zhou, Jiawei Liu, Ruimin Chi, Tao Xu

Bone & Joint Research  ·  01 Apr 2022  ·  doi:10.1302/2046-3758.114.BJR-2021-0192.R1

Whole Transcriptome Mapping Identifies an Immune- and Metabolism-Related Non-coding RNA Landscape Remodeled by Mechanical Stress in IL-1β-Induced Rat OA-like Chondrocytes

Jiaming Zhang, Xiaoxia Hao, Ruimin Chi, Jiawei Liu, Xingru Shang, Xiaofeng Deng, Jun Qi, Tao Xu

Frontiers in Genetics  ·  03 Mar 2022  ·  doi:10.3389/fgene.2022.821508

2021

Target identification and drug discovery by data-driven hypothesis and experimental validation in ovarian endometriosis

Minuo Yin, Jiaming Zhang, Xinliu Zeng, Hanke Zhang, Ying Gao

Fertility and Sterility  ·  01 Aug 2021  ·  doi:10.1016/j.fertnstert.2021.01.027

SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth

Siyuan Su, Jianfeng Chen, Yao Jiang, Ying Wang, Tamara Vital, …, Alex W. Prevatte, Natalie K. Barker, Laura E. Herring, Ian J. Davis, Pengda Liu

Advanced Science  ·  01 Jun 2021  ·  doi:10.1002/advs.202004846

Predicted Disease-Specific Immune Infiltration Patterns Decode the Potential Mechanisms of Long Non-Coding RNAs in Primary Sjogren’s Syndrome

Caiqi Cheng, Jun Zhou, Ruiying Chen, Yo Shibata, Reina Tanaka, Jun Wang, Jiaming Zhang

Frontiers in Immunology  ·  14 Apr 2021  ·  doi:10.3389/fimmu.2021.624614

Moderate mechanical stress suppresses the IL‐1β‐induced chondrocyte apoptosis by regulating mitochondrial dynamics

Jiaming Zhang, Xiaoxia Hao, Ruimin Chi, Jun Qi, Tao Xu

Journal of Cellular Physiology  ·  06 Apr 2021  ·  doi:10.1002/jcp.30386

The gut microbiota in osteoarthritis: where do we stand and what can we do?

Xiaoxia Hao, Xingru Shang, Jiawei Liu, Ruimin Chi, Jiaming Zhang, Tao Xu

Arthritis Research & Therapy  ·  27 Jan 2021  ·  doi:10.1186/s13075-021-02427-9

2020

Promising targets and drugs in rheumatoid arthritis

Xingyan Li, Yejing Yang, Guili Sun, Wanwu Dai, Xuri Jie, Yongjun Du, Runjie Huang, Jiaming Zhang

Bone & Joint Research  ·  01 Aug 2020  ·  doi:10.1302/2046-3758.98.bjr-2019-0301.r1

Effects of body weight‐supported treadmill training on cartilage‐subchondral bone unit in the rat model of posttraumatic osteoarthritis

Xiaoxia Hao, Shengjie Wang, Jiaming Zhang, Tao Xu

Journal of Orthopaedic Research  ·  31 Jul 2020  ·  doi:10.1002/jor.24791

Constructing knowledge graphs and their biomedical applications

David N. Nicholson, Casey S. Greene

Computational and Structural Biotechnology Journal  ·  01 Jan 2020  ·  doi:10.1016/j.csbj.2020.05.017

2019

Long non-coding RNA in osteogenesis

J. Zhang, X. Hao, M. Yin, T. Xu, F. Guo

Bone & Joint Research  ·  01 Feb 2019  ·  doi:10.1302/2046-3758.82.bjr-2018-0074.r1

Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission

Xudong Yao, Jiaming zhang, Xingzhi Jing, Yaping Ye, Jiachao Guo, Kai Sun, Fengjing Guo

Pharmacological Research  ·  01 Jan 2019  ·  doi:10.1016/j.phrs.2018.09.026

2018

Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes

Shuang Liang, Zheng-tao Lv, Jia-ming Zhang, Yu-ting Wang, Yong-hui Dong, …, Qing Yang, Feng-jing Guo, Wei-wei Lu, Wen-tao Zhu, An-min Chen

Frontiers in Pharmacology  ·  27 Nov 2018  ·  doi:10.3389/fphar.2018.01378

Identification of Skt11-regulated genes in chondrocytes by integrated bioinformatics analysis

Shuang Liang, Jia-ming Zhang, Zheng-tao Lv, Peng Cheng, Wen-tao Zhu, An-min Chen

Gene  ·  01 Nov 2018  ·  doi:10.1016/j.gene.2018.08.013

Long noncoding RNA LINC00152 as a novel predictor of lymph node metastasis and survival in human cancer: a systematic review and meta-analysis

Jiaming Zhang, Minuo Yin, Junming Huang, Zhengtao Lv, Shuang Liang, Xiaoao Miao, Fang Huang, Yingchao Zhao

Clinica Chimica Acta  ·  01 Aug 2018  ·  doi:10.1016/j.cca.2018.03.034

FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB Activation and CXCL10 Expression

Zheng-tao Lv, Shuang Liang, Kun Chen, Jia-ming Zhang, Peng Cheng, Jia-chao Guo, Qing Yang, Chen-he Zhou, Hui Liao, An-min Chen

BioMed Research International  ·  30 May 2018  ·  doi:10.1155/2018/3936257

Sci-Hub provides access to nearly all scholarly literature

Daniel S Himmelstein, Ariel Rodriguez Romero, Jacob G Levernier, Thomas Anthony Munro, Stephen Reid McLaughlin, Bastian Greshake Tzovaras, Casey S Greene

eLife  ·  01 Mar 2018  ·  doi:10.7554/eLife.32822

CRNDE: An important oncogenic long non‐coding RNA in human cancers

Jiaming Zhang, Minuo Yin, Gang Peng, Yingchao Zhao

Cell Proliferation  ·  05 Feb 2018  ·  doi:10.1111/cpr.12440

Role of IFT88 in icariin‑regulated maintenance of the chondrocyte phenotype

Wei Xiang, Jiaming Zhang, Rui Wang, Limei Wang, Shengjie Wang, Yingxing Wu, Yonghui Dong, Fengjing Guo, Tao Xu

Molecular Medicine Reports  ·  25 Jan 2018  ·  doi:10.3892/mmr.2018.8486

2017

Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR

Jiachao Guo, Weijin Li, Yingxing Wu, Xingzhi Jing, Junming Huang, …, Wei Xiang, Ranyue Ren, Zhengtao Lv, Jun Xiao, Fengjing Guo

Frontiers in Pharmacology  ·  04 Oct 2017  ·  doi:10.3389/fphar.2017.00693

CD146+ skeletal stem cells from growth plate exhibit specific chondrogenic differentiation capacity in vitro

Ying-Xing Wu, Xing-Zhi Jing, Yue Sun, Ya-Ping Ye, Jia-Chao Guo, Jun-Ming Huang, Wei Xiang, Jia-Ming Zhang, Feng-Jing Guo

Molecular Medicine Reports  ·  26 Sep 2017  ·  doi:10.3892/mmr.2017.7616

HDAC6 inhibition suppresses chondrosarcoma by restoring the expression of primary cilia

Wei Xiang, Fengjing Guo, Weiting Cheng, Jiaming Zhang, Junming Huang, Rui Wang, Zhongxi Ma, Kai Xu

Oncology Reports  ·  01 Jan 2017  ·  doi:10.3892/or.2017.5694

2016

Effect of Ulinastatin in the Treatment of Postperative Cognitive Dysfunction: Review of Current Literature

Zheng-tao Lv, Jun-ming Huang, Jin-ming Zhang, Jia-ming Zhang, Jin-feng Guo, An-min Chen

BioMed Research International  ·  01 Jan 2016  ·  doi:10.1155/2016/2571080